PMID: 18272811

Sonawane ND, Zegarra-Moran O, Namkung W, Galietta LJ, Verkman AS
Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.
J Pharmacol Exp Ther. 2008 May;325(2):529-35. Epub 2008 Feb 13., [PubMed]
Sentences
No. Mutations Sentence Comment
179 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 18272811:179:145
status: NEW
view ABCC7 p.Gly551Asp details
 An interior binding site is mandated by the data in Fig. 8 of Routaboul et al. (2007), showing remarkably weaker CFTR inhibition after mutation (G551D) at a residue located in a cytosolic domain of CFTR. Login to comment