PMID: 18223673

Schmidt A, Hughes LK, Cai Z, Mendes F, Li H, Sheppard DN, Amaral MD
Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.
Br J Pharmacol. 2008 Mar;153(6):1311-23. Epub 2008 Jan 28., [PubMed]
Sentences
No. Mutations Sentence Comment
246 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 18223673:246:175
status: NEW
view ABCC7 p.Trp1282* details
 In support of this idea, Lim et al. (2004) demonstrated that concentrations of genistein exceeding 5 mM caused a dose-dependent loss of the viability of IB3-1 cells ((F508del/W1282X) bronchial epithelial cells) after 72 h of treatment, while Li et al. (2004) reported similar results with Madin Darby canine kidney epithelial cells using genistein (100 mM). Login to comment