PMID: 18183034

Wyen C, Fuhr U, Frank D, Aarnoutse RE, Klaassen T, Lazar A, Seeringer A, Doroshyenko O, Kirchheiner JC, Abdulrazik F, Schmeisser N, Lehmann C, Hein W, Schomig E, Burger DM, Fatkenheuer G, Jetter A
Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients.
Clin Pharmacol Ther. 2008 Jul;84(1):75-82. Epub 2008 Jan 9., [PubMed]
Sentences
No. Mutations Sentence Comment
127 ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 18183034:127:265
status: NEW
view ABCB1 p.Asn21Asp details
ABCB1 p.Asn21Asp
X
ABCB1 p.Asn21Asp 18183034:127:267
status: NEW
view ABCB1 p.Asn21Asp details
 Genotyping for the CYP3A5*3 allele was done as described using a melting curve analysis technique.45,46 Genotyping for P-glycoprotein was done by direct sequencing of the MDR1 exons 2, 12, 21, and 26, including the single nucleotide polymorphisms C-4T, G-1A, A61G (Asn21Asp), C1236T (synonymous), G2677T (Ala893Ser), G2677A (Ala893Thr), and C3435T (synonymous). Login to comment