ABCMdb

PMID: 18023072

Mueller C, Torrez D, Braag S, Martino A, Clarke T, Campbell-Thompson M, Flotte TR
Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene.
J Gene Med. 2008 Jan;10(1):51-60., [PubMed]

Sentences

No. Mutations Sentence Comment

35 ABCC7 p.Ser489* Mouse strains The primary CFTR knockout strain used for these studies was the CFTR S489X -/- neo insertion in C57BL/6 mice developed initially at the University of North Carolina [41] and then modified with the transgenic overexpression of gut-specific expression of human CFTR from the fatty acid binding protein (FABP) promoter in order to prevent intestinal obstruction and improve viability [42]. Login to comment 46 ABCC7 p.Ser489* Aspergillus sensitization and challenge Five- to six-week old CFTR S489X -/-; FABP-hCFTR (+/+), and C57BL/6J mice were house in the SPF mouse colony of the University of Florida according to NIH guidelines and were allowed food and water ad libitum. Login to comment