PMID: 18003606

De Rosa MF, Ackerley C, Wang B, Ito S, Clarke DM, Lingwood C
Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog.
J Biol Chem. 2008 Feb 22;283(8):4501-11. Epub 2007 Nov 13., 2008-02-22 [PubMed]
Sentences
No. Mutations Sentence Comment
213 ABCB1 p.Phe343Cys
X
ABCB1 p.Phe343Cys 18003606:213:69
status: NEW
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 In contrast, no inhibition with adaGb3 pretreatment was seen for the F343C containing mutants. Login to comment 270 ABCB1 p.Leu339Cys
X
ABCB1 p.Leu339Cys 18003606:270:68
status: NEW
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ABCB1 p.Phe728Cys
X
ABCB1 p.Phe728Cys 18003606:270:74
status: NEW
view ABCB1 p.Phe728Cys details
 C, panel i, membranes prepared from HEK 293 cells expressing mutant L339C/F728C were preincubated for 15 min at 22 °C with different concentrations of adaGb3 (0-500 ␮M) (lanes 2-6). Login to comment 291 ABCB1 p.Leu339Cys
X
ABCB1 p.Leu339Cys 18003606:291:20
status: NEW
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 Modification of the L339C residue altered signal transduction from several distinct MDR1 drug-binding sites (73), suggesting adaGb3 should prove effective against many MDR1 substrates. Login to comment 292 ABCB1 p.Phe343Cys
X
ABCB1 p.Phe343Cys 18003606:292:127
status: NEW
view ABCB1 p.Phe343Cys details
ABCB1 p.Phe343Cys
X
ABCB1 p.Phe343Cys 18003606:292:129
status: NEW
view ABCB1 p.Phe343Cys details
 AdaGb3/MDR1 binding may be similar to colchicine, demecolcine, Hoescht 33342, or flupentixol that similarly do not inhibit TM6 F343C disulfide cross-linking (33). Login to comment