PMID: 17983806

Fiorotto R, Spirli C, Fabris L, Cadamuro M, Okolicsanyi L, Strazzabosco M
Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion.
Gastroenterology. 2007 Nov;133(5):1603-13. Epub 2007 Sep 2., [PubMed]
Sentences
No. Mutations Sentence Comment
24 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 17983806:24:164
status: NEW
view ABCC7 p.Ser489* details
 The composition (in mmol/L) of perfusion buffers used was essentially as described.3,4,13 Experimental Animals Congenic B6.129P2-Cftrtm1Unc mice, which possess the S489X mutation that blocks transcription of CFTR,14 and èc;F508-CFTR (B6-129-Cftrtm1Kth) mice with targeted mutation corresponding to the èc;F508 mutation in human, were used as described.15 For further information, see the supplementary online material (see Supplementary Material online at www.gastrojournal.org). Login to comment