PMID: 17979513

Husain A, Loehle JA, Hein DW
Clinical pharmacogenetics in pediatric patients.
Pharmacogenomics. 2007 Oct;8(10):1403-11., [PubMed]
Sentences
No. Mutations Sentence Comment
62 ABCC1 p.Val105Ile
X
ABCC1 p.Val105Ile 17979513:62:99
status: NEW
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 The lower-activity GSTP1 polymorphism at 1578A>G (GSTP1*B), which results in the amino acid change Val105Ile, is associated with higher etoposide clearance in African-Americans treated with steroids, possibly by inducing ABCB1-medicated drug efflux [19]. Login to comment 137 ABCB1 p.Thr1065Gly
X
ABCB1 p.Thr1065Gly 17979513:137:109
status: NEW
view ABCB1 p.Thr1065Gly details
 A significant genotype-dose interaction and small to moderately favorable effects across all ratings for the T1065G SNP suggest that subjects homozygous for the T allele have improved dose responses in comparison with the variant G allele [62]. Login to comment