PMID: 17936667

Boncoeur E, Criq VS, Bonvin E, Roque T, Henrion-Caude A, Gruenert DC, Clement A, Jacquot J, Tabary O
Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression.
Int J Biochem Cell Biol. 2008;40(3):432-46. Epub 2007 Sep 1., [PubMed]
Sentences
No. Mutations Sentence Comment
1 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 17936667:1:227
status: NEW
view ABCC7 p.Trp1282* details
 We here report the effects of oxidative stress (hyperoxia, 95% O2) on the expression of pro-inflammatory interleukin (IL)-8 and CXCR1/2 receptors in two human CF lung epithelial cell lines (IB3-1, with the heterozygous F508del/W1282X mutation and CFBE41o- with the homozygous F508del/F508del mutation) and two control non-CF lung epithelial cell lines (S9 cell line derived from IB3-1 after correction with wtCFTR and the normal bronchial cell line 16HBE14o-). Login to comment 46 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 17936667:46:153
status: NEW
view ABCC7 p.Trp1282* details
 Cell culture and hyperoxia-mediated oxidative stress IB3-1 is a bronchial epithelial cell line derived from a CF patient with a CFTR genotype of F508del/W1282X. Login to comment