PMID: 17805562

Mehta A
The cystic fibrosis transmembrane recruiter the alter ego of CFTR as a multi-kinase anchor.
Pflugers Arch. 2007 Nov;455(2):215-21. Epub 2007 Sep 6., [PubMed]
Sentences
No. Mutations Sentence Comment
113 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 17805562:113:17
status: NEW
view ABCC7 p.Gly551Asp details
 For example, the G551D mutation is an example that Fig. 1 CFTR modelled as a pair of scissors with each ATP trapped in a finger hole and sandwiched between the two ATP binding domains. Login to comment 123 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 17805562:123:3
status: NEW
view ABCC7 p.Gly551Asp details
 In G551D, for example, the G551 residue lies within a molecular lid that traps one gamma phosphate of ATP between the first and second nucleotide binding domains. Login to comment 124 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 17805562:124:29
status: NEW
view ABCC7 p.Gly551Asp details
 The extra negative charge in G551D means that this lid is malformed, perhaps being more repulsive to phosphate. Login to comment