PMID: 17680777

Skach WR
Pharmacological chaperoning: two 'hits' are better than one.
Biochem J. 2007 Sep 1;406(2):e1-2., 2007-09-01 [PubMed]
Sentences
No. Mutations Sentence Comment
47 ABCC7 p.His1085Arg
X
ABCC7 p.His1085Arg 17680777:47:70
status: NEW
view ABCC7 p.His1085Arg details
 Steady-state levels (determined by immunoblotting) of the CFTR mutant H1085R revealed that combinations of corr-2b/VRT325 or corr-4a/ corr-2b rescued more CFTR than each compound independently. Login to comment 48 ABCC7 p.His1085Arg
X
ABCC7 p.His1085Arg 17680777:48:113
status: NEW
view ABCC7 p.His1085Arg details
 Similar additive effects were observed for combinations of corr-2b/VRT325 or corr-4a/corr-2b for the CFTR mutant H1085R, in which the second nucleotide-binding domain was removed. Login to comment