ABCMdb

PMID: 17655203

Mukhamedova N, Fu Y, Bukrinsky M, Remaley AT, Sviridov D
The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux.
Biochemistry. 2007 Aug 21;46(33):9388-98. Epub 2007 Jul 26., [PubMed]

Sentences

No. Mutations Sentence Comment

269 ABCA1 p.Trp590Ser ABCA1 p.Trp590Ser ABCA1 p.Gln597Arg ABCA1 p.Cys1477Arg ABCA1 p.Arg587Trp ABCA1 p.Ser1506Leu Natural mutations found in the Tangier pedigree, R587W, W590S, Q597R, and S1506L, as well as generated mutant C1477R strongly inhibited cholesterol and phospholipid efflux (28, 35, 36) and, with the exception of W590S, also apoA-I binding (36). Login to comment 288 ABCA1 p.Trp590Ser Other mutations (e.g., W590S) inhibited cholesterol efflux with apoA-I binding intact (30, 35, 36). Login to comment 315 ABCA1 p.Trp590Ser As with the ABCA1 mutant W590S (35, 36), the antibody NDF4C2 inhibited cholesterol efflux without affecting apoA-I binding to ABCA1. Login to comment