PMID: 17621683

Edafiogho IO, Kombian SB, Ananthalakshmi KV, Salama NN, Eddington ND, Wilson TL, Alexander MS, Jackson PL, Hanson CD, Scott KR
Enaminones: Exploring additional therapeutic activities.
J Pharm Sci. 2007 Oct;96(10):2509-31., [PubMed]
Sentences
No. Mutations Sentence Comment
92 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 17621683:92:219
status: NEW
view ABCC1 p.Ala893Ser details
 The most commonly identified linked MDR1 SNPs (linkage disequilibrium) in P-gp are the synonymous 1236 (exon 12, C > T, Glu 412 Glu) and 3435 (exon 26, C > T, Ile 1145 Ile) and the nonsynonymous 2677 (exon 21, G > T/A, Ala 893 Ser/Thr [less frequent]113 ) plymorphisms.102,114-118 To date, discrepancies in the outcomes of genotype-phenotype studies are attributed to the emphasis on studying single SNPs rather than haplotypes, racial variation in allele fre- quencies119 and the number of haplotype combinations,120 the use of P-gp substrates which are affected by other transporters or metabolizing enzymes, and other interfering factors (route of administration and applied dose, steady state versus single-dose kinetics, environmental and experimental factors). Login to comment