PMID: 17585883

Leitner HM, Kachadourian R, Day BJ
Harnessing drug resistance: using ABC transporter proteins to target cancer cells.
Biochem Pharmacol. 2007 Dec 15;74(12):1677-85. Epub 2007 May 21., [PubMed]
Sentences
No. Mutations Sentence Comment
122 ABCC10 p.His322Met
X
ABCC10 p.His322Met 17585883:122:729
status: NEW
view ABCC10 p.His322Met details
ABCC10 p.His322Met
X
ABCC10 p.His322Met 17585883:122:869
status: NEW
view ABCC10 p.His322Met details
 One of the best-recognized concepts in radiation biology is that the presence of oxygen increases the efficacy of Table 3 - Expression of multidrug resistant ABC transporters in cancer cells as previously reported [30] Cell type Transportera ABCB1 (MDR1) ABCC1 (MRP1) ABCC2 (MRP2) ABCC3 (MRP3) ABCC4 (MRP4) ABCC5 (MRP5) ABCC10 (MRP7) ABCG2 (BCRP) Breast BT-549 + + ++ + +++ ++ ++ + HS578T ++ + + +++ + +++ +++ ++ MCF7 Æ + Æ Æ Æ +++ ++ +++ NCI_ADR_RES +++ ++ Æ Æ Æ ++ +++ Æ Colon COLO205 Æ ++ +++ +++ + + Æ +++ HCC-2998 Æ + +++ +++ Æ +++ Æ +++ HCT-116 Æ ++ +++ ++ ++ ++ +++ + HCT-15 +++ + Æ Æ + ++ + Æ HT29 Æ ++ Æ +++ ++ Æ ++ +++ Lung A549-ATCC Æ + ++ + +++ ++ +++ + NCI-H226 Æ ++ ++ +++ ++ Æ + Æ NCI-H23 Æ ++ +++ Æ + Æ Æ +++ NCI-H322M Æ +++ +++ +++ + ++ +++ +++ NCI-H460 +++ ++ +++ +++ Æ + Æ +++ NCI-H522 + ++ Æ + + +++ ++ Æ Leukemia HL-60 ++ ++ Æ Æ +++ +++ + Æ MOLT-4 Æ ++ Æ Æ + +++ + Æ RPMI-8226 + ++ Æ Æ +++ + + +++ SR Æ + Æ + + Æ + Æ Ovarian IGROV1 +++ ++ + Æ +++ +++ Æ Æ OVCAR-3 Æ ++ Æ Æ + ++ ++ Æ OVCAR-4 Æ Æ + Æ ++ ++ +++ + OVCAR-5 Æ ++ Æ +++ +++ ++ + Æ OVCAR-8 +++ ++ Æ Æ ++ ++ ++ Æ Prostate DU-145 + ++ +++ +++ ++ + + ++ PC-3 Æ ++ Æ ++ + +++ ++ Æ Renal 786-0 +++ ++ Æ +++ + ++ ++ +++ A498 +++ + +++ +++ ++ Æ Æ Æ ACHN +++ + Æ +++ ++ Æ ++ + CAKI-1 +++ + + + + ++ ++ Æ RXF-393 Æ Æ + ++ +++ + +++ + UO-31 +++ + Æ +++ ++ ++ +++ Æ a High expression (+++); moderate expression (++); low expression (+); very low to no expression (W). Login to comment