PMID: 17569884

Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, Catanese JJ, Pullinger CR, Leong DU, Arellano AR, Tong CH, Movsesyan I, Naya-Vigne J, Noordhof C, Feric NT, Malloy MJ, Topol EJ, Koschinsky ML, Devlin JJ, Ellis SG
A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease.
Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):2030-6. Epub 2007 Jun 14., [PubMed]
Sentences
No. Mutations Sentence Comment
99 ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 17569884:99:640
status: VERIFIED
view ABCG2 p.Val12Met details
 Unadjusted Association of 5 SNPs With Severe CAD in Study 1 and Study 2 SNP ID Gene Symbol Chromosome Study Major Allele* Minor Allele* Type of SNP* Case AF† Control AF† OR‡ CI P Value§ rs3798220 LPA 6 1 A G I4399M 0.04 0.01 3.79 1.97-7.29 Ͻ0.001 2 A G 0.04 0.02 2.25 1.27-3.97 0.010 rs3814843 CALM1 14 1 T G 3ЈUTR 0.05 0.03 1.66 1.11-2.49 0.012 2 T G 0.06 0.04 1.74 1.13-2.67 0.020 rs4796603 HAP1 17 1 A T T58S 0.83 0.79 1.34 1.10-1.63 0.004 2 A T 0.83 0.78 1.36 1.09-1.68 0.012 rs6453373 AP3B1 5 1 A T E585V 0.94 0.92 1.51 1.11-2.04 0.008 2 A T 0.93 0.90 1.50 1.09-2.05 0.022 rs2231137 ABCG2 4 1 G A V12M 0.97 0.95 1.60 1.08-2.37 0.020 2 G A 0.96 0.94 1.62 1.10-2.38 0.028 *The polymorphic nucleotides on the sense strands are shown. Login to comment