PMID: 17557942

Quinton PM
Cystic fibrosis: lessons from the sweat gland.
Physiology (Bethesda). 2007 Jun;22:212-25., [PubMed]
Sentences
No. Mutations Sentence Comment
292 ABCC7 p.Arg117His
X
ABCC7 p.Arg117His 17557942:292:258
status: NEW
view ABCC7 p.Arg117His details
 Neither the basis nor the role of these phenomenon are understood, but when glutamate or precursors and ATP were applied to CF ducts from patients of different genotypes, those ducts from patients with a "mild" phenotype (pancreatic sufficient: ⌬F508/R117H) exhibited a significantly larger (almost normal) HCO3 - conductance, whereas ducts from patients with a "severe" phenotype (pancreatic insufficient: ⌬F508/⌬F508) remained impermeable to HCO3 - (132). Login to comment