ABCMdb

PMID: 17495126

Winkler M, Stephan D, Bieger S, Kuhner P, Wolff F, Quast U
Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A + B-site ligands.
J Pharmacol Exp Ther. 2007 Aug;322(2):701-8. Epub 2007 May 10., [PubMed]

Sentences

No. Mutations Sentence Comment

5 ABCC8 p.Ser1237Tyr A-ligands are highly selective in closing the pancreatic channel, whereas B-ligands are nonselective and insensitive to the mutation S1237Y. Login to comment 33 ABCC8 p.Ser1237Tyr In addition, their potency in closing the pancreatic channel was not affected by the mutation S1237Y in SUR1 (Ashfield et al., 1999; Hansen et al., 2002). Login to comment 39 ABCC8 p.Ser1237Tyr We evaluated the effect of coexpression with Kir6.x on the affinity of SURx for the insulinotropes, the effect of the mutation SUR2(Y1206S), i.e., the reverse of the mutation SUR1(S1237Y), and the selectivity in binding to the recombinant pancreatic, myocardial, and vascular KATP channels. Login to comment