PMID: 17397012

Ray AS, Cihlar T
Unlikely association of multidrug-resistance protein 2 single-nucleotide polymorphisms with tenofovir-induced renal adverse events.
J Infect Dis. 2007 May 1;195(9):1389-90; author reply 1390-1., [PubMed]
Sentences
No. Mutations Sentence Comment
0 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 17397012:0:399
status: NEW
view ABCC2 p.Val417Ile details
 CORRESPONDENCE • JID 2007:195 ( May) • 1389 1 M A Y Correspondence Unlikely Association of Multidrug-Resistance Protein 2 Single-Nucleotide Polymorphisms with Tenofovir-Induced Renal Adverse Events To the Editor-Izzedine et al. [1] reported an association between ABCC2 encoding the multidrug-resistance protein 2 [MRP2] gene polymorphism 1249 GrA leading to a nonsynonymous change of Val to Ile at position 417 and renal proximal tubulopathy induced by tenofovir. Login to comment 3 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 17397012:3:50
status: NEW
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 Prior reports cast doubt on the importance of the Val417Ile substitution in MRP2 function. Login to comment 5 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 17397012:5:69
status: NEW
view ABCC2 p.Val417Ile details
 Furthermore, in vitro functional studies have demonstrated that MRP2 Val417Ile substitution affects neither the expression, membrane localization of the transporter, nor transport efficiency observed for structurally diverse substrates [3]. Login to comment