PMID: 17346156

Xu J, Peng H, Zhang JT
Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy.
Curr Med Chem. 2007;14(6):689-701., [PubMed]
Sentences
No. Mutations Sentence Comment
31 ABCG2 p.Lys86Met
X
ABCG2 p.Lys86Met 17346156:31:53
status: VERIFIED
view ABCG2 p.Lys86Met details
 Moreover, the non-functional ABCG2 mutant (bearing a K86M mutation in the Walker A NBD) acted as an effective dominant-negative inhibitor of ABCG2 when co-expressed with a wild type ABCG2 [14, 18]. Login to comment