ABCMdb

PMID: 17324574

Attie AD
ABCA1: at the nexus of cholesterol, HDL and atherosclerosis.
Trends Biochem Sci. 2007 Apr;32(4):172-9. Epub 2007 Feb 26., [PubMed]

Sentences

No. Mutations Sentence Comment

142 ABCA1 p.Trp590Ser This is supported by studies of the Trp590Ser ABCA1 mutant, which binds to apo-A1 but does not promote efficient cholesterol efflux and releases the apo-A1 in an unlipidated form [70,71]. Login to comment 155 ABCA1 p.Trp590Ser This is also true of the Trp590Ser mutant mentioned earlier. Login to comment 156 ABCA1 p.Trp590Ser Mutations in the ATP-binding modules of the Trp590Ser mutant prevent binding to apo-A1 [69], predicting that the multimeric form is the one bound by apo-A1. Login to comment