ABCMdb

PMID: 17214987

Carrier I, Urbatsch IL, Senior AE, Gros P
Mutational analysis of conserved aromatic residues in the A-loop of the ABC transporter ABCB1A (mouse Mdr3).
FEBS Lett. 2007 Jan 23;581(2):301-8. Epub 2007 Jan 3., [PubMed]

Sentences

No. Mutations Sentence Comment

93 ABCB1 p.Ser43Gly ABCB1 p.Asp178His D551/ D1196 D178 Q100 Q471/ Q1114 K429/K1072 G423/G1066 K45 G39 Y397/Y1040 P O O O P O O O P O O O N N N N N Ser-41 Wat-500 Wat-443 N G426/G1069 C427/C1070 G428/G1071 K429/K1072 D551/D1196 Q471/Q1114 E552/E1197 H583/H1228 S425/S1068 S430/S1073 T431/T1074 O - Wat-445 O - Wat-407 2- Wat-437 Wat-415 Lys-45 Gly-44 Ser-43 Gly-42 Asp-178 His-211 Glu-179 Gln-100 O O O K401/R1043 Q531/Q1176 Wat-488 His-19 Gln-158 Ser-46 Thr-47 A B C D Y16 O N N N N N Wat-644 Wat-538 Wat-424 Wat-467 Y397/Y1040 O Tyr-16 L H V I D L H K R Y VQ F SGF V F N Y HisP mMdr3 hMDR1 V T FGE V V F N Y 160(208)/279 GG H . Login to comment 95 ABCB1 p.Ser43Gly ABCB1 p.Ser43Gly ABCB1 p.Asp178His ABCB1 p.Asp178His D551/ D1196 D178 Q100 Q471/ Q1114 K429/K1072 G423/G1066 K45 G39 Y397/Y1040 PO O O PO O O P O O O N N N N N Ser-41 Wat-500 Wat-443 NG426/G1069 C427/C1070 G428/G1071 K429/K1072 D551/D1196 Q471/Q1114 E552/E1197 H583/H1228 S425/S1068 S430/S1073 T431/T1074 O- Wat-445 O- Wat-407 2- Wat-437 Wat-415 Lys-45 Gly-44 Ser-43 Gly-42 Asp-178 His-211Glu-179Gln-100 O O O K401/R1043 Q531/Q1176 Wat-488 His-19 Gln-158 Ser-46 Thr-47 A B C D Y16 O N N N N N Wat-644 Wat-538 Wat-424 Wat-467 Y397/Y1040 OTyr-16 L H V I D L H K R Y VQ F SGF V F N Y HisP mMdr3 hMDR1 V T FGE V V F N Y 160(208)/279 GG H . Login to comment