PMID: 17187268

Bakos E, Homolya L
Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1).
Pflugers Arch. 2007 Feb;453(5):621-41. Epub 2006 Dec 23., [PubMed]
Sentences
No. Mutations Sentence Comment
32 ABCC9 p.His69Arg
X
ABCC9 p.His69Arg 17187268:32:179
status: NEW
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 Structure of MRP1 and the role of the amino-terminal regions The cDNA encoding MRP1 was first cloned from a doxorubicin-selected, multidrug resistant human lung cancer cell line (H69R) by differential cDNA screening [24]. Login to comment 97 ABCC1 p.Trp261Ala
X
ABCC1 p.Trp261Ala 17187268:97:198
status: NEW
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ABCC1 p.Lys267Met
X
ABCC1 p.Lys267Met 17187268:97:205
status: NEW
view ABCC1 p.Lys267Met details
ABCC1 p.Trp222Leu
X
ABCC1 p.Trp222Leu 17187268:97:177
status: NEW
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ABCC1 p.Trp223Leu
X
ABCC1 p.Trp223Leu 17187268:97:184
status: NEW
view ABCC1 p.Trp223Leu details
 Typical substrates, which are transported as glutathione or glucuronide conjugates, e.g., LTC4 or E217βG, are not transported by an MRP1 variant mutated in the L0 region (W222L, W223L, R231A, W261A, K267M). Login to comment