PMID: 17185998

de Jong FA, Scott-Horton TJ, Kroetz DL, McLeod HL, Friberg LE, Mathijssen RH, Verweij J, Marsh S, Sparreboom A
Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein.
Clin Pharmacol Ther. 2007 Jan;81(1):42-9., [PubMed]
Sentences
No. Mutations Sentence Comment
51 ABCC2 p.Val417Ile
X
ABCC2 p.Val417Ile 17185998:51:389
status: NEW
view ABCC2 p.Val417Ile details
 Table 3 Functional consequences of investigated ABCC2 polymorphisms ABCC2 genotype Position Effecta Activityb NCBI ID Reference ABCC2 À1549G4A 50 -Flanking - Unknown rs1885301 Innocenti et al.28 ABCC2 À1019A4G 50 -Flanking - Unknown rs2804402 Innocenti et al.28 ABCC2 À24C4T 50 -UTR - Decreased rs717620 Ito et al.,31 Itoda et al.,32 Haenisch et al.39 ABCC2 1249G4A Exon 10 V417I Unknown rs2273697 Ito et al.,31 Itoda et al.,32 Kroetz et al.38 ABCC2 IVS26 -34T4C Intron 26 - Unknown rs8187698 Kroetz et al.38 ABCC2 3972C4T Exon 28 I324I Unknown rs3740066 Ito et al.,31 Itoda et al.32 NCBI ID, National Center for Biotechnology Information identification number; 50 -UTR, five prime untranslated region. Login to comment