PMID: 17092765

Assaraf YG
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.
Drug Resist Updat. 2006 Aug-Oct;9(4-5):227-46. Epub 2006 Nov 7., [PubMed]
Sentences
No. Mutations Sentence Comment
196 ABCG2 p.Lys86Met
X
ABCG2 p.Lys86Met 17092765:196:103
status: VERIFIED
view ABCG2 p.Lys86Met details
 First, co-introduction of both a wild type as well as a catalytically null mutant ABCG2 cDNA bearing a K86M mutation in the consensus Walker A motif in the NBF resulted in a negative-dominant effect thereby abolishing ABCG2 function (Ozvegy et al., 2001, 2002). Login to comment