PMID: 17017890

Tsakovska I, Pajeva I
Phenothiazines and structurally related compounds as modulators of cancer multidrug resistance.
Curr Drug Targets. 2006 Sep;7(9):1123-34., [PubMed]
Sentences
No. Mutations Sentence Comment
76 ABCB1 p.Phe983Ala
X
ABCB1 p.Phe983Ala 17017890:76:50
status: NEW
view ABCB1 p.Phe983Ala details
 It was demonstrated that a single substitution of alanine for phenylalanine at position 983 in the putative TM12 of Pgp markedly altered the ability of the stereoizomers to modulate ATP hydrolysis and [125 I] IAAP labeling of Pgp and also affected inhibition of Pgp-mediated transport by both isomers of flupentixol. Login to comment