PMID: 16926162

Loo TW, Bartlett MC, Clarke DM
Insertion of an arginine residue into the transmembrane segments corrects protein misfolding.
J Biol Chem. 2006 Oct 6;281(40):29436-40. Epub 2006 Aug 22., [PubMed]
Sentences
No. Mutations Sentence Comment
81 ABCC7 p.Leu1260Ala
X
ABCC7 p.Leu1260Ala 16926162:81:267
status: NEW
view ABCC7 p.Leu1260Ala details
 The I306R mutation was introduced into mutants containing a processing mutation in the TM segments (G300V in TM5, G722A in TM7), the loops connecting the TM segments (G251V in intracellular loop 2, F804A in intracellular loop 3), the linker region (P709A), and NBD2 (L1260A) (Fig. 1A). Login to comment 83 ABCC7 p.Leu1260Ala
X
ABCC7 p.Leu1260Ala 16926162:83:137
status: NEW
view ABCC7 p.Leu1260Ala details
 The I306R mutation was more efficient, however, in promoting maturation of mutants G251V, G300V, P709A, and G722A than mutants F804A and L1260A. Login to comment 100 ABCC7 p.Leu1260Ala
X
ABCC7 p.Leu1260Ala 16926162:100:152
status: NEW
view ABCC7 p.Leu1260Ala details
 A, immunoblot analysis of whole cell extracts of HEK 293 cells expressing the A52-tagged P-gp processing mutants G251V, G300V, P709A, G722A, F804A, and L1260A with or without the I306R mutation. Login to comment