ABCMdb

PMID: 16897043

Bryan J, Munoz A, Zhang X, Dufer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L
ABCC8 and ABCC9: ABC transporters that regulate K+ channels.
Pflugers Arch. 2007 Feb;453(5):703-18. Epub 2006 Aug 8., [PubMed]

Sentences

No. Mutations Sentence Comment

141 ABCC8 p.His1023Tyr ABCC8 p.Ile1424Val Analysis of two SUR1 mutant channels, I1424V or H1023Y, demonstrated they were more active than wild-type channels both in on-cell recordings from intact mammalian cells and in isolated patches exposed to a quasiphysiologic concentration of MgATP (1 mM). Login to comment 142 ABCC8 p.His1023Tyr ABCC8 p.Ile1424Val In the absence of Mg2+ , when the stimulatory action of SUR1 on the pore was abolished, there was no significant difference in the ATP inhibitory curves of mutant and wild-type channels, indicating the I1424V or H1023Y receptors exert an enhanced stimulatory action on the pore. Login to comment 143 ABCC8 p.His1023Tyr The simulation of heterozygosity by expression of 1:1 mixtures of ND-SUR1 H1023Y and wild-type SUR1 with KIR6.2 produced average mean channel activities intermediate between the "homozygous" mutant and wild-type channels. Login to comment