PMID: 16895999

Kroetz DL
Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity.
J Clin Oncol. 2006 Sep 10;24(26):4225-7. Epub 2006 Aug 8., [PubMed]
Sentences
No. Mutations Sentence Comment
27 ABCC1 p.Ala893Ser
X
ABCC1 p.Ala893Ser 16895999:27:323
status: NEW
view ABCC1 p.Ala893Ser details
 The current study reported by Michael et al suggests that UGT1A1 genotype alone may not be sufficient to identify patients who would benefit from a lower starting dose of irinotecan.16 They also genotyped for three common coding region variants of ABCB1, two synonymous changes, and a nonsynonymous change resulting in the Ala893Ser variant of Pgp. Login to comment