PMID: 16863439

Jedlitschky G, Hoffmann U, Kroemer HK
Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition.
Expert Opin Drug Metab Toxicol. 2006 Jun;2(3):351-66., [PubMed]
Sentences
No. Mutations Sentence Comment
72 ABCC11 p.Arg1096Lys
X
ABCC11 p.Arg1096Lys 16863439:72:85
status: NEW
view ABCC11 p.Arg1096Lys details
 Substitution of Arg at position 586 in rat Mrp2 with Leu and Ile and substitution of Arg at position 1096 with Lys, Leu and Met resulted in the acquisition of taurocholate transport activity, while retaining transport activity for GSH and glucuronate conjugates [42]. Login to comment