PMID: 16828872

Marcet B, Boeynaems JM
Relationships between cystic fibrosis transmembrane conductance regulator, extracellular nucleotides and cystic fibrosis.
Pharmacol Ther. 2006 Dec;112(3):719-32. Epub 2006 Jul 10., [PubMed]
Sentences
No. Mutations Sentence Comment
555 ABCC7 p.Arg117His
X
ABCC7 p.Arg117His 16828872:555:228
status: NEW
view ABCC7 p.Arg117His details
 Increased ADO is not expected to improve mucociliary clearance in CF lungs because A2B receptor-mediated stimulation of CFTR channel activity is defective (Boucher, 1994a, 1994b), although an A2B receptor-mediated activation of R117H-CFTR has been demonstrated (Clancy et al., 1999). Login to comment