PMID: 16828748

Koch J, Guntrum R, Tampe R
The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding.
FEBS Lett. 2006 Jul 24;580(17):4091-6. Epub 2006 Jun 30., [PubMed]
Sentences
No. Mutations Sentence Comment
21 ABCB3 p.Leu410Phe
X
ABCB3 p.Leu410Phe 16828748:21:161
status: NEW
view ABCB3 p.Leu410Phe details
 However, previous studies suggest that TAP and tapasin interact through their TMs, since soluble human tapasin variants and a transmembrane domain point mutant (L410F) were defective in TAP association and consequently impaired in MHC class I surface presentation [21]. Login to comment