PMID: 16804061

Stalvey MS, Muller C, Schatz DA, Wasserfall CH, Campbell-Thompson ML, Theriaque DW, Flotte TR, Atkinson MA
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes. 2006 Jul;55(7):1939-45., [PubMed]
Sentences
No. Mutations Sentence Comment
38 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 16804061:38:55
status: NEW
view ABCC7 p.Ser489* details
RESEARCH DESIGN AND METHODS We used mice with the CFTR S489X-/- neo insertion, developed initially at the University of North Carolina (20). Login to comment
42 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 16804061:42:5
status: NEW
view ABCC7 p.Ser489* details
CFTR S489X-/- FABP-hCFTRϩ/ϩ (hereafter designated CFTR-/- ), C57BL/6J, and FVB/NJ mice were housed under specific pathogen-free conditions at the University of Florida Animal Care Services according to National Institutes of Health guidelines and allowed food and water ad libitum. Login to comment
56 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 16804061:56:5
status: NEW
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CFTR S489X-/- animals (4-6 weeks old) were sensitized to Aspergillus fumigatus crude protein extract (Greer Laboratories, Lenoir, NC). Login to comment
66 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 16804061:66:47
status: NEW
view ABCC7 p.Ser489* details
Lung, intestine, and pancreatic mRNA from CFTR S489X-/- FABP-hCFTR؉/؉ mice was used to analyze the expression pattern of the hCFTR driven by the FABP promoter by RT-PCR, using gene-specific primers for hCFTR and B-actin control primers. Login to comment
180 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 16804061:180:24
status: NEW
view ABCC7 p.Ser489* details
Interestingly, the CFTR S489X-/- FABP-hCFTRϩ/ϩ model used in this experiment has not been previously reported to have pancreatic disease. Login to comment