ABCMdb

PMID: 16798073

Cavelier C, Lorenzi I, Rohrer L, von Eckardstein A
Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1.
Biochim Biophys Acta. 2006 Jul;1761(7):655-66. Epub 2006 May 4., [PubMed]

Sentences

No. Mutations Sentence Comment

129 ABCA1 p.Trp590Ser All ABCA1 mutants - except ABCA1(W590S) - which fail to promote cholesterol efflux also fail to cross-link apoA-I [55,56]. Login to comment 130 ABCA1 p.Trp590Ser All ABCA1 mutants - except ABCA1(W590S) - which fail to promote cholesterol efflux also fail to cross-link apoA-I [55,56]. Login to comment 131 ABCA1 p.Trp590Ser Interestingly, the ABCA1 (W590S) mutant cross-links apoA-I better than the wild-type ABCA1 but fails to mediate cholesterol efflux. Login to comment 132 ABCA1 p.Trp590Ser Interestingly, the ABCA1 (W590S) mutant cross-links apoA-I better than the wild-type ABCA1 but fails to mediate cholesterol efflux. Login to comment 136 ABCA1 p.Trp590Ser The carboxy-terminal truncation mutant however showed reduced binding affinity to normal ABCA1 and ABCA1 (W590S). Login to comment 137 ABCA1 p.Trp590Ser The carboxy-terminal truncation mutant however showed reduced binding affinity to normal ABCA1 and ABCA1 (W590S). Login to comment