PMID: 16765145

Tran A, Jullien V, Alexandre J, Rey E, Rabillon F, Girre V, Dieras V, Pons G, Goldwasser F, Treluyer JM
Pharmacokinetics and toxicity of docetaxel: role of CYP3A, MDR1, and GST polymorphisms.
Clin Pharmacol Ther. 2006 Jun;79(6):570-80. Epub 2006 May 2., [PubMed]
Sentences
No. Mutations Sentence Comment
144 ABCB1 p.Ala313Gly
X
ABCB1 p.Ala313Gly 16765145:144:1149
status: NEW
view ABCB1 p.Ala313Gly details
ABCB1 p.Ala313Gly
X
ABCB1 p.Ala313Gly 16765145:144:1190
status: NEW
view ABCB1 p.Ala313Gly details
 Genetic characteristics of patients (N ϭ 58) and toxicity data SNP Genotype Patients evaluable for febrile neutropenia Patients with febrile neutropenia (%) Patients evaluable for grade 3 or grade 4 neutropenia Patients with grade 3 or grade 4 neutropenia: Absolute neutrophil count Ͻ1000/␮L (%) Patients with grade 4 neutropenia: Absolute neutrophil count Ͻ500/␮L (%) CYP3A5 (A6986G) *1/*3 11 1 (9.1) 11 9 (77.8) 7 (63.6) *3/*3 47 6 (12.8) 45 35 (81.8) 21 (46.7) CYP3A4 (-A392G) *1A/*1A 54 7 (13.0) 52 41 (78.8) 26 (50.0) *1A/*1B 4 0 4 3 (75.0) 2 (50.0) MDR1 C3435T C/C 11 0 11 6 (54.5) 5 (45.5) C/T 36 6 (16.7) 35 28 (80.0) 16 (45.7) T/T 11 1 (9.1) 10 10 (100)† 7 (70.0) MDR1 G2677T G/G 25 3 (12.0) 24 17 (70.8) 11 (45.8) G/T 23 2 (8.7) 22 17 (77.3) 11 (50.0) T/T 10 2 (20.0) 10 10 (100) 6 (60.0) GSTM1 Wild type 22 2 (9.1) 21 17 (81.0) 11 (52.4) Absent allele 36 5 (13.9) 35 27 (77.1) 17 (48.6) GSTT1 Wild type 41 4 (9.8) 40 33 (82.5) 22 (55.0) Absent allele 17 3 (17.6) 16 11 (68.8) 6 (37.5) GSTP1 *A/*A 27 1 (3.7) 25 21 (84.0) 14 (56.0) *A (wild type) *A/*B 19 6 (31.6)† 19 15 (78.9) 10 (52.6) *B (A313G) *A/*C 3 0 3 2 (66.7) 1 (33.3) *C (A313G ϩ C341T) *B/*B 7 0 7 5 (71.4) 3 (42.9) *D (C341T) *B/*C 2 0 2 1 (50.0) 0 GSTM3 *A (wild type) *A/*A 40 5 (12.5) 39 29 (74.4) 19 (48.7) *B (A310C) *A/*B 18 2 (11.1) 17 15 (88.2) 9 (52.9) †P Ͻ .05. initely conclude that it is clinically relevant. Login to comment