PMID: 16723978

Guggino WB, Stanton BA
New insights into cystic fibrosis: molecular switches that regulate CFTR.
Nat Rev Mol Cell Biol. 2006 Jun;7(6):426-36., [PubMed]
Sentences
No. Mutations Sentence Comment
111 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 16723978:111:34
status: NEW
view ABCC7 p.Gly551Asp details
 Genistein, a flavinoid, activates G551D-CFTR channels - which are present in the plasma membrane, but are inactive - and ∆F508-CFTR channels. Login to comment 112 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 16723978:112:61
status: NEW
view ABCC7 p.Gly551Asp details
 Therefore, genistein might be useful in individuals with the G551D mutation, and might enhance ∆F508-CFTR-mediated Cl-secretion in patients who also receive a drug that increases the membrane expression of ∆F508-CFTR. Login to comment