PMID: 16621465

Cernicka J, Subik J
Resistance mechanisms in fluconazole-resistant Candida albicans isolates from vaginal candidiasis.
Int J Antimicrob Agents. 2006 May;27(5):403-8. Epub 2006 Apr 18., [PubMed]
Sentences
No. Mutations Sentence Comment
81 ABCB1 p.Val437Ile
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ABCB1 p.Val437Ile 16621465:81:39
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 With the exception of K128T, E266D and V437I [15,32], no data are available regarding the confirmed participation in azole resistance of other amino acid substitutions resulting from our ERG11 sequenced amplicons. Login to comment 92 ABCB1 p.Val437Ile
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ABCB1 p.Val437Ile 16621465:92:547
status: NEW
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 FLU and 4-NQO, but not ITR and TER, are acknowledged substrates of this efflux pump [18,27,33] belonging to the class Table 2 Amino acid substitutions in Erg11p from Candida albicans isolatesa Candida albicans isolate Amino acid substitutions Allelic state of mutation 63 D116E Heterozygous K128T Heterozygous 193 P49R/T Heterozygous E266D Homozygous T486P Heterozygous V488I Homozygous 208 D116E Heterozygous K119L Heterozygous E266D Heterozygous 222 E266D Homozygous V488I Homozygous 235 Y33C Heterozygous Y39C Heterozygous W54Stop Heterozygous V437I Homozygous L491V Heterozygous T494A Heterozygous a Substitutions conserved in fluconazole-resistant strains are written in bold. Login to comment