PMID: 16614351

Pan J, Luk C, Kent G, Cutz E, Yeger H
Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice.
Am J Respir Cell Mol Biol. 2006 Sep;35(3):320-6. Epub 2006 Apr 13., [PubMed]
Sentences
No. Mutations Sentence Comment
131 ABCC7 p.Ser489*
X
ABCC7 p.Ser489* 16614351:131:384
status: NEW
view ABCC7 p.Ser489* details
 Because NEB represent airway O2 sensors (analogous to carotid body chemoreceptors) involved in the control of breathing (2, 4), the previously mentioned abnormalities could partly account for recent observation of decreased ventilatory responses to hypoxia observed in Cftr-/- mice using whole-body plethysmography (20) and decreased compliance and increased airway resistance in the S489X Cftr-/- mouse (21). Login to comment