ABCMdb

PMID: 16393888

Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ
Metabolism and transport of oxazaphosphorines and the clinical implications.
Drug Metab Rev. 2005;37(4):611-703., [PubMed]

Sentences

No. Mutations Sentence Comment

627 ABCC1 p.Arg433Ser Substitution of Arg433 with Ser predicted to be close to TM8 of MRP1 caused by the low frequency G1299T polymorphism in exon 10 leads to a substrate selective change in organic anion transport activity and drug resistance using MRP1-expressing HeLa cells (Conrad et al., 2002) or human leukemia CEM-7A cells (Assaraf et al., 2003). Login to comment 628 ABCC1 p.Cys43Ser The 128C MRP1 polymorphism in exon 2 resulting in Cys43Ser substitution disrupted plasma membrane trafficking and reduced resistance to doxorubicin, vincristine, and arsenite in HeLa cells expressing this MRP1 mutant while the transport of conjugated organic anion remained comparable to wild type MRP1 (Ito et al., 2001a; Leslie et al., 2003). Login to comment 637 ABCC5 p.Gly1249Ala These mainly included C-24T (promoter), G1249A (exon 10), G2026C (exon 16), T2125C (exon 17), C2302T (exon 18), C2366 (exon 18), A3517T (exon 25), G3449 (exon 25), C3972T (exon 28), and G4348A (exon 31). Login to comment