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PMID: 16393888
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ
Metabolism and transport of oxazaphosphorines and the clinical implications.
Drug Metab Rev. 2005;37(4):611-703.,
[PubMed]
Sentences
No.
Mutations
Sentence
Comment
627
ABCC1 p.Arg433Ser
X
ABCC1 p.Arg433Ser 16393888:627:16
status:
NEW
view ABCC1 p.Arg433Ser details
Substitution of
Arg433 with Ser
predicted to be close to TM8 of MRP1 caused by the low frequency G1299T polymorphism in exon 10 leads to a substrate selective change in organic anion transport activity and drug resistance using MRP1-expressing HeLa cells (Conrad et al., 2002) or human leukemia CEM-7A cells (Assaraf et al., 2003).
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628
ABCC1 p.Cys43Ser
X
ABCC1 p.Cys43Ser 16393888:628:50
status:
NEW
view ABCC1 p.Cys43Ser details
The 128C MRP1 polymorphism in exon 2 resulting in
Cys43Ser
substitution disrupted plasma membrane trafficking and reduced resistance to doxorubicin, vincristine, and arsenite in HeLa cells expressing this MRP1 mutant while the transport of conjugated organic anion remained comparable to wild type MRP1 (Ito et al., 2001a; Leslie et al., 2003).
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637
ABCC5 p.Gly1249Ala
X
ABCC5 p.Gly1249Ala 16393888:637:40
status:
NEW
view ABCC5 p.Gly1249Ala details
These mainly included C-24T (promoter),
G1249A
(exon 10), G2026C (exon 16), T2125C (exon 17), C2302T (exon 18), C2366 (exon 18), A3517T (exon 25), G3449 (exon 25), C3972T (exon 28), and G4348A (exon 31).
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