PMID: 16387301

Deeley RG, Cole SP
Substrate recognition and transport by multidrug resistance protein 1 (ABCC1).
FEBS Lett. 2006 Feb 13;580(4):1103-11. Epub 2005 Dec 21., 2006-02-13 [PubMed]
Sentences
No. Mutations Sentence Comment
146 ABCC1 p.Asn590Ala
X
ABCC1 p.Asn590Ala 16387301:146:9
status: NEW
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 However, alanine substitution of Asn590 affects transport of a variety of substrates, apparently by reducing the binding of ATP by NBD1 [76], although other amino acid substitutions have no effect. Login to comment 147 ABCC1 p.Phe594Ala
X
ABCC1 p.Phe594Ala 16387301:147:25
status: NEW
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 On the other hand, while alanine substitution of Phe594 eliminates LTC4 binding and overall transport activity, conservative mutations have differential effects on substrate specificity suggesting that this residue may interact directly with substrate [61]. Login to comment