PMID: 16338273

Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K
Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.
Clin Pharmacol Ther. 2005 Dec;78(6):559-81., [PubMed]
Sentences
No. Mutations Sentence Comment
204 ABCB1 p.Ser1141Thr
X
ABCB1 p.Ser1141Thr 16338273:204:392
status: NEW
view ABCB1 p.Ser1141Thr details
 In a single report the 893Ser variant of P-glycoprotein showed a significant increase in function by use of digoxin as a substrate.170 However, with the use of a variety of substrates, other investigators have failed to find any difference in function between the reference and 893Ser variant of P-glycoprotein.164,171,172 To date, there are no functional data on the common African American Ser1141Thr variant of P-glycoprotein. Login to comment