PMID: 16257832

Mizutani T, Hattori A
New horizon of MDR1 (P-glycoprotein) study.
Drug Metab Rev. 2005;37(3):489-510., [PubMed]
Sentences
No. Mutations Sentence Comment
117 ABCB3 p.Glu552Gln
X
ABCB3 p.Glu552Gln 16257832:117:0
status: NEW
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 E552Q- E1197Q mutation abolished drug-stimulated ATPase activity as measured by release of phosphate, and the results support a model in which two NBDs of MDR1 are not functionally equivalent. Login to comment 121 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 16257832:121:45
status: NEW
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 Colchicine stimulated ATPase activity of the G185V mutant of MDR1, suggesting a tight regulation of ATPase activity by colchicine and the position of G185 was shown in structure model (Omote et al., 2004). Login to comment 167 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 16257832:167:19
status: NEW
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ABCB1 p.Ile186Asn
X
ABCB1 p.Ile186Asn 16257832:167:25
status: NEW
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 MDR1 with mutation G185V-I186N altered the magnitude of drug-induced increases in UIC2 immunoreactivity (Ruth, 2001). Login to comment