ABCMdb

PMID: 16110776

Akins RA
An update on antifungal targets and mechanisms of resistance in Candida albicans.
Med Mycol. 2005 Jun;43(4):285-318., [PubMed]

Sentences

No. Mutations Sentence Comment

40 ABCB1 p.Arg467Lys ABCB1 p.Arg467Lys Strong evidence for another four mutants was provided by showing reduced susceptibilities of demethylase activity from clinical resistant Table 1 Mutations in ERG11 that confer FLZ resistance, and their methods of determination Mutation Effect Method(s) Ref Y132H(F) Altered FLZ binding, no reduction in activity; resistant transformants SDM, confers SDD, confers R in combination with S405F; SDM-EA;/Ca(Sc) confers R growth in combination with G450E; combinations may confer R to posaconazole [11,284,285] T315A Altered FLZ binding, altered heme binding, reduced activity; resistant transformants SDM confers R; SDM-EA [286] R467K Altered heme, reduced FLZ binding; resistant transformants SDM confers SDD; confers R in combination with G464S; SDM-EA [18,287,288] G464S Altered heme, reduced FLZ binding, reduced activity; resistant transformants SDM-EA; /Ca(Sc) confers SDD, confers increased SDD in combination with G129A (a susceptible polymorphism), confers R in combination with R467K, may confer R to posaconazole in combination with G307S [18,289/291] A61V Resistant clinical strain with other mutations, resistant transformants /Ca(Sc) confers SDD growth [291] K143E/ T229A Found together in resistant isolates, resistant enzyme, resistant transformants /Ca(Sc) confers SDD growth; EA [12,291,292] S405F Found in resistant isolates, unique mutation in some, also found in sensitive isolates in combination with other mutations, resistant transformants /Ca(Sc) confers SDD; confers R in combination with Y132H [12,18] G450E Found with other mutations in many resistant strains, resistant enzyme; resistant transformants /Ca(Sc) confers R growth in combination with Y132H; EA [12,291,292] F72L Found in one resistant strain with other mutations, resistant enzyme EA [292] F126L Found in one strain with other mutations, resistant enzyme EA [292] E266D Found with other mutations in many resistant strains, resistant enzyme EA [12,292] F449L Found in strains with other mutations, resistant enzyme EA [12,292] F105L Found in resistant isolates, unique ERG11 mutation in some Correlative, located in substrate access channel in model [12,290] Abbreviations: SDD/susceptible, dose-dependent (resistant in vitro to 8/32 mg/ml FLZ); R: resistant in vitro to 64/mg/ml FLZ). Login to comment