PMID: 16103896

Thompson JF, Man M, Johnson KJ, Wood LS, Lira ME, Lloyd DB, Banerjee P, Milos PM, Myrand SP, Paulauskis J, Milad MA, Sasiela WJ
An association study of 43 SNPs in 16 candidate genes with atorvastatin response.
Pharmacogenomics J. 2005;5(6):352-8., [PubMed]
Sentences
No. Mutations Sentence Comment
5 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 16103896:5:232
status: NEW
view ABCB1 p.Ser893Ala details
 The only significant associations with LDL-C lowering were found with apoE2 in which carriers of the rare allele who took atorvastatin lowered their LDL-C by 3.5% more than those homozygous for the common allele and with rs2032582 (S893A in ABCB1) in which the two groups of homozygotes differed by 3% in LDL-C lowering. Login to comment 57 ABCB1 p.Ser893Ala
X
ABCB1 p.Ser893Ala 16103896:57:147
status: NEW
view ABCB1 p.Ser893Ala details
ABCB1 p.Ser1141Thr
X
ABCB1 p.Ser1141Thr 16103896:57:201
status: NEW
view ABCB1 p.Ser1141Thr details
 N ¼ 160 Cauc. N ¼ 2454 Hisp. N ¼ 85 Best P Statin Ref. ABC B1 rs2229109 7 86 824 460 Ser400Asn 0 1.2 3.8 1.8 rs2032582 7 86 805 269 Ser893Ala 40.0 89.4 56.7 60.2 rs17149694 7 86 783 310 Ser1141Thr 0 6.2 0.02 0.6 rs1045642 7 86 783 296 Ile1145Ile 50.0 79.0 48.7 50.0 0.023 Atorva 9 ABC G5 rs6720173 2 43 952 052 Gln604Glu 20.8 33.1 16.8 32.5 ABC G8 rs11887534 2 43 977 898 Asp19His 1.4 3.9 5.4 6.6 0.036 Atorva 17 rs4148211 2 43 983 394 Tyr54Cys 29.2 23.1 37.4 32.5 rs4148217 2 44 011 334 Thr400Lys 10.0 24.0 18.1 30.1 rs6544718 2 44 016 576 Val632Ala 6.9 5.9 21.8 18.7 ACE rs4331 17 58 917 784 Ala157Ala 72.2 43.2 43.8 53.0 0.005 Fluva 18 rs4341 17 58 919 722 72.2 43.8 44.0 51.9 0.005 Fluva 18 Apo AI rs670 11 116 213 623 Promoter G/A 20.8 14.4 16.4 21.1 HDLC Prava 19 ApoE rs429358 19 50 103 781 E4 (Cys130Arg) 8.3 29.0 17.7 17.7 0.043 Lova 20 rs7412 19 50 103 919 E2 (Cys176Arg) 2.8 5.0 3.7 1.2 0.01 Atorva 21 19 50 106 239 SNP17 5.6 13.5 7.3 2.4 5 CETP rs1800775 16 55 552 735 CÀ629A 51.6 57.3 48.2 48.1 HDLC Atorva 22 rs708272 16 55 553 789 TaqIB 46.8 25.7 42 42.5 HDLC Atorva 22 Cyp3A4 rs4986910 7 99 003 175 Met445Thr 0 0.9 0.8 0 0.05 Atorva 23 rs2740574 7 99 026 747 AÀ392G 4.7 56.2 3.9 11.4 0.038 Atorva 23 Cyp3A5 rs776746 7 98 915 190 *3 40.6 64.2 7.4 27.2 0.026 24 rs10264272 7 98 907 486 *6, Lys208Lys 1.6 8.7 0.07 3.2 Cyp7A1 rs3808607 8 59 575 478 33.3 56.8 39.3 31.9 0.001 Atorva 25 FDFT1 rs2686196 8 11 697 311 0 0.6 1.4 0.6 HMGCR 5 74 681 677 Asn204Ser 0.0 0.0 0.2 0.0 rs5908 5 74 687 955 Val638Ser 0.0 0.3 1.7 1.2 rs2303151 5 74 691 457 11.1 2.9 4.9 4.8 5 74 691 504 SNP29 0.0 8.5 2.8 2.9 0.003 Prava 5 LDLR rs5925 19 11 091 881 Val653Val, AvaII 40.3 23.1 47.0 56.7 0.05 Fluva 26 rs688 19 11 088 602 Asn591Asn, HincII 36.1 13.0 46.8 46.3 LIPC rs1800588 15 56 510 967 CÀ514T 40.3 49.1 23.1 45.7 0.01 Prava 27 LPL rs1801177 8 19 849 988 Asp9Asn 0 3.9 1.3 1.2 rs268 8 19 857 809 Asn291Ser 0 0.3 1.7 0.6 rs328 8 19 864 004 Ser447X 11.1 8.2 11.2 9.1 OATP C 12 21 185 236 CÀ540T 5.6 3.8 5.0 10.8 12 21 216 983 *2, Phe73Leu 0 0 0.04 0 rs2291073 12 21 217 081 25.0 52.4 8.3 10.0 rs4149036 12 21 219 007 31.9 49.4 21.0 20.5 rs2306283 12 21 221 005 Asn130Asp, *1b 61.1 74.4 40.6 40.9 PK Prava 28 rs11045819 12 21 221 080 Pro155Thr, *4 2.8 9.7 15.8 8.5 rs4149056 12 21 222 816 Val174Ala, *5 8.3 3.8 16.0 14.5 PK Prava 28 12 21 250 200 Gly488Ala, *9 0 5.0 0 0 rs4149080 12 21 268 826 29.2 15.4 17.4 15.2 12 21 283 243 Leu643Phe 1.4 5.3 5.8 3.7 The genes and SNPs examined are listed in columns 1 and 2 with dbSNP identifiers, if available. Login to comment