PMID: 16002665

Otahal P, Hutchinson SC, Mylin LM, Tevethia MJ, Tevethia SS, Schell TD
Inefficient cross-presentation limits the CD8+ T cell response to a subdominant tumor antigen epitope.
J Immunol. 2005 Jul 15;175(2):700-12., [PubMed]
Sentences
No. Mutations Sentence Comment
157 ABCB2 p.Val405Leu
X
ABCB2 p.Val405Leu 16002665:157:452
status: NEW
view ABCB2 p.Val405Leu details
ABCB2 p.Val405Leu
X
ABCB2 p.Val405Leu 16002665:157:547
status: NEW
view ABCB2 p.Val405Leu details
 Table I. SV40 T Ag-transformed cell lines used in this study Cell Designation Cell Type Transforming Agent T Ag Construct H-2b CTL Epitopes Present References B6/T5Aa C57BL/6 embryo fibroblasts pLM234 WT I, II/III, IV, V 30 B6/T116A1 C57BL/6 embryo fibroblasts pSLM361-11 èc;207-215, èc;223-231, Y406A, F408A, C411A (V-only T Ag) V 31 B6/K-0 C57BL/6 kidney pPVU0 WT I, II/III, IV, V 45 B6/K-1,4a C57BL/6 kidney Derived from K-0 èc;134-263, V405L V 45 B6/K-1,4-SVb C57BL/6 kidney Derived from K-1,4 af9; pSV2neo-SV40 èc;134-263, V405L T Ag af9; WT I, II/III, IV, V 45 B6/122B1 (B6 èc;I, II/III, IV, V T Ag) C57BL/6 embryo fibroblasts PLMTS364-1 N210A, N227A, F408A, N493A (no CTL epitopes) None 31 TAP1afa;/afa; wt B6.129S2-Tap1tm1Arp kidney pPVU0 WT I, II/III, IV, V This study TAP1afa;/afa; 361-11 B6.129S2-Tap1tm1Arp kidney pSLM361-11 èc;207-215, èc;223-231, Y406A, F408A, C411A (V-only T Ag) V This study a K-0 epitope loss variant selected by coculture with T Ag-specific CTL clones in vitro. Login to comment