PMID: 15891392

Van Eck M, Pennings M, Hoekstra M, Out R, Van Berkel TJ
Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis.
Curr Opin Lipidol. 2005 Jun;16(3):307-15., [PubMed]
Sentences
No. Mutations Sentence Comment
33 ABCA1 p.Trp590Ser
X
ABCA1 p.Trp590Ser 15891392:33:94
status: NEW
view ABCA1 p.Trp590Ser details
 However, Fitzgerald and colleagues [32 ] recently demonstrated that a mutant form of ABCA1 (W590S), which avidly binds apoA-I but fails to promote lipid efflux to apoA-I, released apoA-I with the same kinetics as wild-type ABCA1, indicating that release of apoA-I from ABCA1 is independent of lipid transfer. Login to comment