PMID: 15746174

Nagel G, Barbry P, Chabot H, Brochiero E, Hartung K, Grygorczyk R
CFTR fails to inhibit the epithelial sodium channel ENaC expressed in Xenopus laevis oocytes.
J Physiol. 2005 May 1;564(Pt 3):671-82. Epub 2005 Mar 3., 2005-05-01 [PubMed]
Sentences
No. Mutations Sentence Comment
184 ABCC7 p.Thr663Ala
X
ABCC7 p.Thr663Ala 15746174:184:160
status: NEW
view ABCC7 p.Thr663Ala details
 They found less than 35% inhibition of murine ENaC by activated CFTR (their Fig. 1A), only a modest 20% inhibition for wildtype α-hENaC and no change for T663A α-hENaC, where threonine 663 (wildtype) was replaced by alanine (their Fig. 2). Login to comment