PMID: 15720286

Peer M, Csaszar E, Vorlaufer E, Kopp S, Chiba P
Photoaffinity labeling of P-glycoprotein.
Mini Rev Med Chem. 2005 Feb;5(2):165-72., [PubMed]
Sentences
No. Mutations Sentence Comment
87 ABCB1 p.Phe983Ala
X
ABCB1 p.Phe983Ala 15720286:87:241
status: NEW
view ABCB1 p.Phe983Ala details
 Cell lines expressing wt and mutant proteins were subjected to accumulation studies using Bodipy FL-verapamil in the presence of cis(Z)- or trans(E)- flupentixol. Both flupentixol isomers were shown to loose their inhibitory function in the F983A mutant. Login to comment 88 ABCB1 p.Phe983Ala
X
ABCB1 p.Phe983Ala 15720286:88:101
status: NEW
view ABCB1 p.Phe983Ala details
 The large increase in labeling with [125I]IAAP in the presence of cis(Z)-flupentixol was lost in the F983A mutant. Login to comment 90 ABCB1 p.Phe983Ala
X
ABCB1 p.Phe983Ala 15720286:90:78
status: NEW
view ABCB1 p.Phe983Ala details
 A general loss of sensitivity to inhibitors was excluded, because labeling of F983A with IAAP stayed sensitive to Cyclosporin A inhibition. Login to comment