PMID: 15711774

Zhang ZR, Cui G, Zeltwanger S, McCarty NA
Time-dependent interactions of glibenclamide with CFTR: kinetically complex block of macroscopic currents.
J Membr Biol. 2004 Oct 1;201(3):139-55., 2004-10-01 [PubMed]
Sentences
No. Mutations Sentence Comment
300 ABCC7 p.Ser1118Phe
X
ABCC7 p.Ser1118Phe 15711774:300:118
status: NEW
view ABCC7 p.Ser1118Phe details
ABCC7 p.Val317Glu
X
ABCC7 p.Val317Glu 15711774:300:134
status: NEW
view ABCC7 p.Val317Glu details
 Unblocked macroscopic currents in WT-CFTR and nearly all mutants studied to date are time-independent (exceptions are S1118F-CFTR and V317E-CFTR, which confer voltage-jump relaxations on currents in the absence of added blockers; Zhang, McDonough & McCarty, 2000b; Zhang et al. 2002). Login to comment