PMID: 15709975

Riordan JR
Assembly of functional CFTR chloride channels.
Annu Rev Physiol. 2005;67:701-18., [PubMed]
Sentences
No. Mutations Sentence Comment
97 ABCC7 p.Arg334Cys
X
ABCC7 p.Arg334Cys 15709975:97:5
status: NEW
view ABCC7 p.Arg334Cys details
 This R334C variant exhibited three subconductance states, as does the wild-type, and these states were altered simultaneously and with the same kinetics by a positively charged MTS reagent also making it seem highly unlikely that the segments from more than one CFTR polypeptide come together to form the permeation pathway. Login to comment