PMID: 15678092

Hansen AM, Hansen JB, Carr RD, Ashcroft FM, Wahl P
Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
Br J Pharmacol. 2005 Feb;144(4):551-7., [PubMed]
Sentences
No. Mutations Sentence Comment
28 ABCC8 p.Ser1237Tyr
X
ABCC8 p.Ser1237Tyr 15678092:28:217
status: NEW
view ABCC8 p.Ser1237Tyr details
 Recent studies from our laboratory suggested that the binding site for repaglinide is not identical to that of sulphonylureas, since repaglinide binding and channel inhibition by this drug were unaffected by mutation S1237Y in SUR1, which abolishes KATP channel inhibition by tolbutamide (Hansen et al., 2002). Login to comment