ABCMdb

PMID: 15642363

Milewski MI, Lopez A, Jurkowska M, Larusch J, Cutting GR
PDZ-binding motifs are unable to ensure correct polarized protein distribution in the absence of additional localization signals.
FEBS Lett. 2005 Jan 17;579(2):483-7., [PubMed]

Sentences

No. Mutations Sentence Comment

25 ABCC7 p.His1402Ala ABCC7 p.Arg1403Ala Also, the introduction of the H1402A and R1403A mutations, reducing the aggregation rate of the CFTR C-terminus, was previously described [9]. Login to comment 64 ABCC7 p.His1402Ala ABCC7 p.Arg1403Ala A diagram illustrating the structure and subcellular localization of the GFP fusion proteins containing either the full-length CFTR protein or its C-terminal fragment (a.a. 1370-1480) with two alanine substitutions (H1402A and R1403A), eliminating the aggregation of the CFTR C-terminus. Login to comment 93 ABCC7 p.His1402Ala ABCC7 p.Arg1403Ala (B) Apical localization of the GFP-CFTR 1370-1480 H1402A, R1403A fusion protein containing the C-terminal M-K-D-T-R-L> motif. Login to comment 94 ABCC7 p.His1402Ala ABCC7 p.Arg1403Ala (C) Predominant cytoplasmic distribution of the GFP-CFTR 1370-1480 H1402A, R1403A fusion protein containing the extended Q-K-E-TC-L> PDZ-binding motif of LET23. Login to comment